Patient and transplantation characteristics:
Characteristic Total =150 patients | Haplo transplant (n = 69) | CB transplant (n = 81) | P value |
Patients Age years (median) [range] | 44 (19-68) | 47 (18-66) | |
Patients sex | ns | ||
Male | 39 (57) | 46 (57) | |
Female | 30 (43) | 35 (43) | |
Disease type | |||
AML | 3 (4) | 37 (46) | <0.0001 |
ALL | 1 (1) | 14 (17) | <0.0001 |
NHL | 24 (35) | 14 (17) | ns |
HL | 30 (43) | 2 (2) | <0.0001 |
MM | 4 (6) | 2 (2) | ns |
CLL | 5 (7) | 4 (5) | ns |
CML | 0 | 1 (1) | ns |
MDS/ MPS | 2 (3) | 7 (9) | ns |
Status of disease | |||
CR | 37 (54) | 56 (69) | ns |
PR/SD | 24 (35) | 12 (15) | 0.04 |
PD | 8 (11) | 13 (16) | ns |
Donor type | |||
Sibiling | 32 (46) | ||
Parent | 18 (26) | ||
Child | 18 (26) | ||
cousin | 1 (2) | ||
Donor/recipient sex mis-match | 34 (49) | 56 (69) | ns |
ABO incompatibility | 24 | 56 | 0.02 |
Conditioning regimen | |||
Flu 5+Cy 1+ TBI | 0 | 75 (93) | |
Flu 5+Cy 2+ TBI | 69 (100) | 6 (7) | |
Stem cell source | |||
Peripheral Blood | 19 (28) | ||
Bone Marrow | 50 (72) | ||
Stem cell dose median [range] CD34+ x 106/kg | 3,96 (0,8-14) | 0,9 (0,08-1,28) | |
GvHD prophylaxis | |||
CSA+MMF | 69 (100) | 81 (100) | ns |
Cy post transplant | 69 (100) | 0 | |
Days with ANC< 500 x 109/l | 20 (14-39) | 22 (6-67) | ns |
Days with platelets<20 x 109/l | 29 (14-50) | 41 (18-80) | ns |