Table 4

Univariate Cox regression models for impact of MRDpos status, entire study cohort (n = 253)

CR1 (n = 183)CR2 (n = 70)All (n = 253)
OS
 MRDneg1 (reference)1 (reference)1 (reference)
 MRDpos3.35 (2.02-5.55), P < .0012.68 (1.25-5.74), P = .0113.13 (2.06-4.76); P < .001
 MRD <0.1%2.91 (1.44-5.89);P = .003
 MRD 0.1%-1%2.79 (1.58-4.92); P < .001
 MRD >1%3.98 (2.13-7.46); P < .001
DFS
 MRDneg1 (reference)1 (reference)1 (reference)
 MRDpos4.76 (2.97-7.65); P < .0013.34 (1.65-6.77); P = .0014.15 (2.81-6.13); P < .001
 MRD <0.1%3.93 (2.06-7.48); P < .001
 MRD 0.1%-1%3.22 (1.89-5.50); P < .001
 MRD >1%6.83 (3.84-12.13); P < .001
Relapse
 MRDneg1 (reference)1 (reference)1 (reference)
 MRDpos5.60 (3.16-9.94); P < .0014.84 (2.11-11.06); P < .0015.19 (3.26-8.27); P < .001
 MRD <0.1%5.22 (2.52-10.81); P < .001
 MRD 0.1%-1%4.03 (2.16-7.53); P < .001
 MRD >1%8.13 (4.11-16.07); P < .001
NRM
 MRDneg1 (reference)1 (reference)1 (reference)
 MRDpos3.41 (1.46-7.99); P = .0051.14 (0.23-5.53); P = NS2.48 (1.18-5.21); P = .017
 MRD <0.1%1.85 (0.43-7.86); P = NS
 MRD 0.1%-1%1.93 (0.67-5.57), P=NS
 MRD >1%4.69 (1.59-13.84), P = .005
  • Values are given as hazard ratio (95% confidence interval [CI]), P value.

  • NS, not significant.