Table 2

Clinical characteristic of 22 P2RY8-CRLF2–positive relapse cases

Pt IDSexAge at dx, yMRDRem, moRel siteSourceClonal stability of P2RY8-CRLF2
P2RY8-CRLF2 major clone
    715M8.90IR17BMATConserved
    737M9.50IR25BM + CNSATReduced to minor subclone
    1*F2.00IR33BMDELost
    4F1.40IR42BMDELost
    2*M8.70IR63BMDEConserved
    3M4.60LR65BMDELost
    5*F4.10IR67BMDEConserved
    6F2.70LR98BMDEConserved
P2RY8-CRLF2 minor subclone
    775M13.20IR11BMATLost
    391F12.70IR12BMATConserved
    814F4.60LR18BMATLost
    721M2.50IR20testisATConserved
    778M4.20IR20BMATLost
    810M4.90IR28BM + CNSATLost
    579M1.30IR35BMATLost
    460F5.70IR36BMATLost
    571M9.20IR44BMATLost
    456M12.00IR48BMATConserved
    545M4.70LR55BMATLost
    564*M8.25LR55BMATDifferent minor subclone
    417*F9.7560BMATConserved
    243*F10.40IR71BMATConserved
  • Pt indicates patient; dx, initial diagnosis; MRD, minimal residual disease risk classification; Rem, remission; Rel, relapse; BM, bone marrow; and CNS, central nervous system.

  • * Down syndrome.