Table 5

IPSS-R prognostic risk category clinical outcomes

No. of patientsVery lowLowIntermediateHighVery high
Patients, %70121938201310
Survival, all*8.85.33.01.60.8
(7.8-9.9)(5.1-5.7)(2.7-3.3)(1.5-1.7)(0.7-0.8)
Hazard ratio0.51.02.03.28.0
(95% CI)(0.46-0.59)(0.93-1.1)(1.8-2.1)(2.9-3.5)(7.2-8.8)
Patients, %64851937201311
AML/25%*NR10.83.21.40.73
(14.5-NR)(9.2-NR)(2.8-4.4)(1.1-1.7)(0.7-0.9)
Hazard ratio0.51.03.06.212.7
(95% CI)(0.4-0.6)(0.9-1.2)(2.7-3.5)(5.4-7.2)(10.6-15.2)
  • NR indicates not reached.

  • * Medians, years (95% CI), P < .001.

  • Median time to 25% AML evolution (95% CIs), P < .001.