Table 1

Clinical variables of MDS patients

No. of patients% of patientsSurvival years, medianDxy (95% CI; P*)No. of patients% of patientsAML/25% yDxy (95% CI; P*)
Cytogenetics7012100.256485100.27
    Very good25545.4(.23-.26)2553NR(.24-.31)
    Good5069724.84657729.4
    Intermediate947132.7875142.5
    Poor28341.527641.7
    Very poor45870.745270.7
BM blasts7012100.306485100.47
    0-2%3279475.9(.28-.32)300446NR(.44-.50)
    > 2- < 5%1266184.21172188.5
    5-10%1377192.31263202.2
    > 10%-30%1090161.31046161.0
    > 10%-20%(901)(13)(1.3)(860)(13)(0.93)
    > 20%-30%(189)(3)(1.4)(186)(3)(1.0)
Hemoglobin, g/dL7012100.216485100.16
    ≥ 103377485.5(.19-.23)3109489.5(.12-.19)
    8-< 102464352.92286355.5
    < 81171172.01090172.4
Platelets7012100.236485100.17
    ≥ 1004195605.1(.21-.25)3823598.7(.14-.21)
    50- < 1001469212.81368213.1
    < 501348191.61294203.1
ANC7012100.116485100.16
    ≥ 0.85758824.4(.10-.13)5303829.2(.13-.19)
    < 0.81254181.91182181.9
IPSS-R7012100.436485100.52
    Very low1313198.8(.42-.45)121219NR(.49-.55)
    Low2646385.323953710.8
    Intermediate1433203.01310203.2
    High898131.6857131.4
    Very high722100.8711110.7
Sex7012100.076485100.04
    Male4243613.3(.05-.09)3962615.8(.00-.07)
    Female2769394.82523398.0(.030)
Age7012100.056485−.02
    ≤ 60 y1582235.7(.03-.06)1489238.1(−.05-.01)
    > 60 y5430773.54996776.1(.082)
ECOG Performance Status249636.16248938.09
    0751304.3(.13-.18)748308.8(.04-.15)
    11477592.21473596.3(.005)
    2-4268111.6268113.5
Serum ferritin304943.16274742.11
    ≤ 350 ng/mL1602536.3(.13-.20)143552NR(.05-.17)
    > 350 ng/mL1447474.213124814.5(.004)
Serum LDH425761.12413064.12
    Normal3103734.1(.10-.14)3007739.2(.08-.16)
    High1154272.11123273.2
Serum β2-microglobulin100514.14 (.10-.18)100515.02 (−.08-.11)
    ≤ 2 g/mL263263.8263266.7(.498)
    > 2 g/mL742741.7742744.6
Marrow fibrosis132319.04118318.05
    No1158885.2(.01-.07)10558914.5(−.01-.12)
    Yes165123.2(.004)128114.8(.069)
RBC transfusion dependence293342.26264541.27
    No2003686.9(.23-.29)18086814.5(.22-.32)
    Yes930322.3837322.1
IPSS7008100.376481100.48
    Low2625377.0(.35-.39)239437NR(.45-.51)
    Intermediate-12778403.62541396.1
    Intermediate-21126161.51074171.2
    High47970.947270.7
  • AML/25% indicates time for 25% of patients to develop AML.

  • * All univariate P values not explicitly stated are P < .001.

  • × 109/L.