Table 4

Toxicity data

CategoryToxicity gradeTotal
345
Hematologic1421022
CardiacHypertension/hypotension3104
CoagulationHypofibrinogenemia, coagulopathy, thrombosis, lower gastrointestinal hemorrhage5005
GastrointestinalAnorexia, dehydration, diarrhea4004
Pyrexia1001
Infection45310
MetabolicALT, AST, GGT, bilirubin6309
Amylase, lipase1102
Hypercalcemia, hypocalcemia7007
Hypophosphatemia3003
Hyperglycemia, hypoglycemia6107
Hyperkalemia, hypokalemia4408
Hypernatremia0101
Hyponatremia8008
Hypoalbuminemia5005
Total metabolic176018
NeurologicCerebral ischemia, encephalopathy1012
Peripheral neuropathy: motor and sensory2002
PainAbdominal, extremity, external ear3003
RespiratoryCough, hiccups, hypoxia, pleural effusion, pneumonitis3205
Total patients with toxicity2121322
  • ALT indicates alanine aminotransferase; AST, aspartate aminotransferase; and GGT, gamma glutamyl transpeptidase.