Table 1

Iron and inflammatory markers and erythrocyte stable isotope iron incorporation in Gambian children presenting with either postmalarial or nonmalarial anemia, and supplemented with iron for 30 days

Status on day 1: day of 57Fe oral administrationStatus on day 15: day of 58Fe oral administration
Postmalarial anemiaNonmalarial anemiaPostmalarial anemiaNonmalarial anemia
N11161116
span class=SpellEHb, g/L84 ± 395 ± 3*105 ± 498 ± 2
Hepcidin, ng/mL25.5 ± 7.412.8 ± 5.816.3 ± 5.217.5 ± 4.7
CRP, mg/L54 (30, 84)4 (2, 6)7 (2, 15)4 (2, 6)
Ferritin, ng/mL82 (48, 164)5 (3, 7)25 (17, 33)14 (8, 20)§
Serum iron, μmol/L16.0 ± 1.910.9 ± 0.814.6 ± 1.214.3 ± 1.2
sTfR, mg/L6.6 ± 0.79.3 ± 0.9*8.3 ± 0.67.7 ± 0.9
sTfR-F index4.8 ± 1.822.9 ± 8.3*7.1 ± 0.77.7 ± 0.9
Erythropoeitin, mIU/mL70 (34, 120)23 (3, 55)*10 (8, 12)14 (8, 20)
ZnPP, mmol/mol Hb131 (103, 159)131 (105, 171)117 (87, 148)132 (106, 162)
Stable iron isotope incorporation 14 days after oral administration (%)10.6 ± 3.525.4 ± 3.922.8 ± 4.830.3 ± 4.8
  • Arithmetic means ± SE or geometric means (95% CI).

  • Hb indicates hemoglobin; CRP, C-reactive protein; sTfR, soluble transferrin receptor; ZnPP, zinc protoporphyrin; and CI, confidence interval.

  • * P < .05 by unpaired t test comparing postmalarial to nonmalarial anemia groups.

  • P < .01 by Scheffé posthoc test day 15 vs day 1.

  • P < .001 by unpaired t test comparing postmalarial to nonmalarial anemia groups.

  • § P < .001 by Scheffé posthoc test day 15 vs day 1.

  • P < .01 by unpaired t test comparing postmalarial to nonmalarial anemia groups.

  • P < .05 by Scheffé posthoc test day 15 vs day 1.