Table 3

Cytogenetic response

ResponseImatinib resistantImatinib intolerantTotal
No.%No.%No.%
Response at 24 weeks
    All treated patients*20088288
    Major663324279031
        Complete452320236523
Cumulative response
    Evaluable patients18680266
    Major10154394914053
        Complete7741334111041
Reason for exclusion from evaluable analysis
    No baseline assessment14822
Major cytogenetic response in evaluable patients by dose intensity
    Mean dose < 250 mg/d1/6170/601/128
    Mean dose 250 to < 350 mg/d12/24509/175321/4151
    Mean dose 350 to < 450 mg/d26/455812/215738/6658
    Mean dose 450 to < 550 mg/d53/945618/365071/13055
    Mean dose ≥ 550 mg/d9/17530/009/1753
  • * Patients without a baseline or week 24 assessment were counted as nonresponders.

  • Major cytogenetic response = complete + partial cytogenetic response.