Table 1

Baseline characteristics according to cytogenetic abnormalities

Standard-risk (n = 188)High-risk* (n = 44)P
Age, y (range)72 (65-85)72 (66-83)NS
Hemoglobin, g/dL, mean10.89.6NS
Calcium, mg/dL, mean9.69.5NS
Creatinine, mg/dL, mean1.021.0NS
B2-microglobulin, mg/L, mean3.85.2NS
PCs BM infiltration, %, mean3844NS
S-phase of PCs, %1.51.5NS
ISS stage, %
    I2816
    II4241NS
    III3043
Induction regimen, %
    VMP/VTP49/5150/50NS
Maintenance regimen, %
    VT/VP51/4954/46NS
  • ISS indicates International Staging System; and PCs, plasma cells.

  • * Forty-four of these 232 patients qualified as high-risk (19%); 17 of them (7%) had t(4;14) ± del(13q), 21 patients (9%) had del(17p) ± del(13q), in 3 cases (1%) t(4;14) and del(17p) coexisted, and 3 additional patients (1%) had t(14;16). Only 1 patient had t(4;14) as single CA.