Table 1

Characteristics of adult and pediatric AML patients by SNP status

CharacteristicPediatric AMLCharacteristicAdult AML
IDH1 SNP+ (n = 27)IDH1 SNP (n = 226)PIDH1 SNP+ (n = 30)IDH1 SNP (n = 244)P
N%N%N%N%
SexSex
    Male176312354.399    Male113713756.052
    Female103710346    Female196310744
Age, yAge, y
    Median (range)5.8(0.15-17.2)10.4(0.07-21.6).046*    Median (range)63(22-76)63(18-88).59
    0-2 y12445123    18-55 y11377129
    3-10 y6226931    56-67 y11378334
    > 11 y93310647     > 68 y8279037
Race.55Race.0039*
    White186915777    White206721789
    Black6233015    Black930177
    Asian28126    Asian0073
    Other0063    Other0010
    Unknown121    Unknown1321.00
Ethnicity.19Ethnicity.21
    Hispanic284018    Hispanic2762
    Non-Hispanic239217782    Non-Hispanic289323898
    Unknown29    Unknown00
WBC, × 109/L, median (range)33.2(0.98-495)19.6(0.8-409).240WBC, × 109/L, median (range)26.5(2.7-298)29.8(0.7-274).82
BM blasts, %, median (range)72(22-97)68(0-100).596BM blasts, %, median (range)80(8-97)70(0-99).025*
CytogeneticsCytogenetics
    Normal3134421.426    Normal11467642.83
    t(8;21)282713.747    CBF002212.083
    Abnormal 165212613.336    −7/7q−14158.7
    Abnormal 113134622.274    +8142715.21
    t(6;9)(p23;q34)00731.000    Other11464022.022*
    −7/7q−2873.236    No data665
    −5/5q−00311.000
    +814199.703FLT3/ITD
    Other8332914.033*    Present13487533.140
    No data318    Absent145215167
318
FLT3/ITDFLT3/ITD by karyotype
    Present4152511.527    Normal
    Absent238520189        Present9902941.0053*
    Unknown00        Absent1104159
    Abnormal
        Present1912131.00
        Absent10918386
NPM1 mutationNPM1 mutation
    Present00105.604    Present9357032.823
    Absent2310019195    Absent176515168
    Unknown425    Unknown423
CEBPA mutationCEBPA mutation
    Yes27105.629    Yes00631.000
    No259320695    No2810021797
    Unknown010    Unknown221
  • * Significant P value.

  • CBF abnormality includes t(8;21), inv(16), and t(16;16). Three patients with +8 also have CBF abnormalities, and another 3 have −7/7q−.

  • Two patients with −7/7q− also have +8; another 2 patients with −7/7q− also have t(8;21); and a fifth patient with −7 also has der(8)t(8;21)(q12;p11) as part of a complex karyotype.