Table 7

Mean pharmacokinetic parameters on days 1 and 15 after oral administration of bosutinib 400, 500, and 600 mg

DoseDayMeasureCmax, ng/mLTmax, h*T1/2, hAUC, ng·h/mL
400 mg1No.3333
Mean77.23.0 (3-4)NA1487
CV%76.317.3109.472.2
15No.3323
Mean157.36.0 (6-24)22.62851
CV%17.686.624.416.6
500 mg1No.3333
Mean100.96.0 (6-6)22.12064
CV%35.3010.124.8
15No.3323
Mean200.36.0 (4-8)21.93660
CV%6.033.327.911.4
600 mg1No.12121112
Mean119.94.0 (2-48)24.72074
CV%33.5159.054.120.0
15No.1010610
Mean208.26.0 (3-8)27.03360
CV%35.230.4100.843.5
  • AUC indicates area under the curve; Cmax, maximum concentration; CV%, coefficient of variation; NA, not available; Tmax, time to maximum concentration; and T1/2, elimination half life.

  • * For Tmax, median (range) values are shown instead of mean values.