Table 1.

Notch1 expression in human malignant B- and T-cell lymphoma entities

No. casesLymphoma entityNotch1 protein expression*Epstein-Barr-virusALK-protein
AbsentWeakStrong
8B-CLL1-153 35NDND
9Mantle cell lymphoma54NDND
10Follicle center lymphoma28NDND
8Marginal zone B-cell lymphoma35NDND
10Diffuse large B-cell lymphoma10NDND
8Sporadic Burkitt lymphoma8ND
25Classical HD2514
12ALCL129
  • * Rat monoclonal antibody against human Notch1.

  • Fusion of the nucleophosmin gene (NPM) to ALK.

  • Epstein-Barr virus–encoded RNA.

  • F1-153 Patients with B-cell chronic lymphocytic leukemia. ND, not determined.