Table 1.

V gene profiles and incidence of novel N-glycosylation sites resulting from somatic mutation in patients with FL

VHVLTotal
PatientGermline donorHomology (%)JHNo. sitesGermline donorHomology (%)JLNo. sites
F1V3-4889JH3a1VκIII/A2795Jκ101
F2V3-4892JH3b1VκIV/B396Jκ412
F7V3-4893JH4a2VκI/01286Jκ313
F8V3-4880JH42VκIII/L296Jκ413
F10V3-4889JH4b1VκI/0292Jκ201
F11V3-4891JH6b2VκI/A3097Jκ102
F15V3-4896JH5a1VκIII/L697Jκ412
F12V3-4889JH6b1VκII/A1799Jκ312
F4* V3-1191JH6c2VκIII/L696Jκ413
F72V3-1592JH4b1VκI/A3095Jκ201
F17V3-2191JH41Vλ1c94Jλ201
F6V3-3087JH4b0VκI/01297Jκ211
F3V3-4987JH6b2VκI/01288Jκ113
F14P1 87JH4b1VκIV/B394Jκ101
F5* V4-3483JH21VκIII/A2789Jκ212
F9V4-3986JH5b1VκIV/A2698Jκ201
F16* V4-5986JH4b1Vλ196Jλ212
  • * Expressed as recombinant scFv in P pastorisand in which functional glycosylation was demonstrated.

  • P1 is a member of VH 3 family, but the locus has not been identified.