Table 2

The final Cox regression model

HR (95% CI)PScore
Age, y
 ≤7510
 76-801.13 (0.76-1.69).5491
 >802.40 (1.56-3.71)<.0012
ADL
 >410
 ≤41.67 (1.08-2.56).0201
IADL
 >510
 ≤51.43 (0.96-2.14).0781
CCI
 ≤110
 ≥21.37 (0.92-2.05).1251
ISS
 I1
 II2.37 (1.38-4.09).002
 III3.21 (1.85-5.58)<.001
Chromosome abnormalities
 Favorable1
 Unfavorable1.79 (1.23-2.60).002
 Missing1.13 (0.69-1.83).036
Therapy
 Proteasome inhibitors1
 Lenalidomide0.74 (0.50-1.11).142
  • HRs and relative risks are for OS in patients with the factors as compared with those without the factors. The model was adjusted for ISS, chromosome abnormalities, and therapy. Unfavorable profile defined as t(4;14) or t(14;16) or del17p13.

  • AIC = 1748.918; Harrell C index = 0.7069.