Table 3.

Estimation of NHL and HD incidence rates and SMRs with French population as a comparison, adjusted for age and sex

Lowest estimation of number of RA patients treated by MTX3-150 (N = 27 000)Highest estimation of number of RA patients treated by MTX3-151 (N = 30 000)
95% CI95% CI
NHL
 Incidence rate (per 100 000 person-years)
  Among men37.0(0 -89.4)33.3(0 -80.5)
  Among women18.5(0 -37.0)16.7(0 -33.3)
  Total22.2(4.1-40.4)20.0(3.7-36.3)
 Comparison with the French national incidence
  Observed (expected)18 (15.1)18 (16.7)
  SMR, standardized for age and sex1.2(0.7 -1.9)1.07(0.6 -1.7)
HD
 Incidence rate per 100 000 person-years)
  Among men30.9(0 -78.7)27.8(0 -70.8)
  Among women3.1(0 -10.6)2.8(0 -9.6)
  Total8.6(0 -20.0)7.8(0 -18.0)
 Comparison with the French national incidence
  Observed (expected)7 (0.8)7 (0.9)
  SMR, standardized for age and sex (95% CI) 3-1508.2(3.3-17.0) 3-1507.4(3.0-15.3)
  • F3-150 Estimated from a French national cross-sectional survey.20

  • F3-151 Estimated from 2 independent surveys among rheumatologists.18 19 21 22

  • *P < .001.24