Table 1.

Details of human chemokine receptors described until June 1999

Receptor Amino acids Base pairs Ligand (high affinity)Cellular distribution
XCR1 (GPR5) 333  999Lymphotactin T, B, NK
CXCR1 (IL8RA) 350 1050IL8, GCP-2 N, M, T, NK, Bs, Ms, En
CXCR2 (IL8RB) 355 1065 IL8, GRO-α, GRO-β, GRO-γ, NAP-2, ENA-78, GCP-2 N, M, T, NK, MS, As, Nn, Ms, En
CXCR3 368 1104 IP-10, Mig, I-TAC Activated T
CXCR4* (LESTR, FUSIN) 352 1056 SDF-1α, SDF-1βMyeloid, T, B, Ep, En, DC
CXCR5 (BLR1) 3721116 BCA-1 B
CX3CR1 (V28) 355 1065Fractalkine NK, M, T
CCR1 355 1065 RANTES, MIP-1α, HCC-1, MCP-2, MCP-3, MIP-5, Ckβ8,N, M, T, NK, B, Ms, As, Nn
CCR2A 3741122 MCP-1, MCP-3, MCP-4 M
CCR2B 360 1080MCP-1, MCP-2, MCP-3, MCP-4 M, T, B, Bs
CCR3 3551065 Eotaxin, Eotaxin-2, Eotaxin-3, RANTES, MCP-2,3,4, MIP-5, Eo, Bs, T
CCR4 360 1080 TARC, MDC T, P
CCR5 (ChemR13) 352 1056 RANTES, MIP-1β, MIP-1α, MCP-2 T, M, M∅︀, DC
CCR6 (STRL 22, DRY-6, GPR-CY4, CKR-L3) 374 1122 MIP-3α T, B, DC
CCR7 (BRL2, EBI1) 378 1134 MIP-3β, 6-C-kine,T, B, DC
CCR8*, (TER1, CKR-L1, ChemR1) 355 1065I-309 M, Thymus
CCR9 (GPR-9-6) 369 1107 TECKT, Thymus
D6 (CCR10?) 384 1152 MCP-1, MCP-3placenta, liver
DARC (Duffy antigen) 338 1014 IL-8, GRO-α, RANTES, MCP-1, MCP-3, MCP-4, Eotaxin En, RBC, T
  • * T-lymphocyte[en]tropic HIV-1 coreceptor.

  • Macrophage-tropic HIV-1 coreceptor.

  • Previous chemokine receptor names are given in brackets.

  • N, neutrophil; M, monocyte/macrophage; T, T-lymphocyte; B, B-lymphocyte; NK, natural killer cell; Eo, eosinophil; Bs, basophil; Ms, mast cell; As, astrocyte; Nn, neurone; P, platelet; En, endothelial cell; Ep, epithelial cell; Hp, hepatocyte; DC, dendritic cell; M∅︀, macrophage; RBC, erythrocyte.