Table 3.

FcγRIII on Mast Cells and TNF Released From Mast Cells Are Responsible for the Pathogenesis of Skin Vasculitis

FcRγ 6-19 No. BMMC Transfer (SC)3-150Ear Lesions
−/− + 8 FcRγ +/− 6/8
4FcRγ −/− 0/4
6 FcγRIII −/−0/6
6 TNFαβ −/− 1/6
−/−6 FcRγ +/− 0/6
6FcγRIII −/− 0/6
  • Mice were inoculated with 6-19 hybridoma cells as described in Table 1. Seven days later, BMMC were SC transferred into 6-19–treated FcRγ −/− mice.

  • F3-150 BMMC were prepared as described in Materials and Methods.