Table 1.

Inhibition of Cryoglobulin/RF-Mediated Skin Vasculitis in FcRγ −/− Mice

FcRγ 6-19 No. Serum IgG3 (mg/mL) Ear Lesions Kidney Lesions Serum BUN (mg/dL)
+/−+ 11 8.42 ± 4.17* 11/11 11/11150.0 ± 69.0*
3 <0.01 0/30/3 20.0 ± 2.2
−/− + 12 8.28 ± 2.920/12 12/12 153.1 ± 99.9
3<0.01 0/3 0/3 19.9 ± 7.7
  • FcRγ +/− or FcRγ −/− mice were inoculated with 6-19 hybridoma cells as described in Materials and Methods. Blocks of the ear and kidney as well as blood samples were collected when the FcRγ +/− mice exhibited skin purpura (7 to 12 days after 6-19 administration).

  • * Values for serum IgG3 and BUN represent the mean ± SD and were determined at time of death.

  • Criteria for positive lesions are described in Materials and Methods.