Table 4.

Univariate Analyses of Potential Prognostic Variables

Variable Category DFSSurvival
N Median (yr) Probability of CCR at 5 yr (95% CI) PN Median (yr) Probability of Survival at 5 yr (95% CI)P
Age <60 181 1.5 .35 (.27-.44).03 214 2.1 .35 (.28-.43) <.001
≥6023 1.1 .13 (.05-.32) 42 0.2 .09 (.03-.22)
Continuous 204 <.001 256<.001
WBC count <30,000 130 2.3.40 (.30-.51) <.001 155 2.4 .37 (.28-.47).001
≥30,000 73 0.8 .18 (.10-.31) 1001.1 .21 (.13-.32)
Log WBC count 203<.001 255 <.001
Mediastinal massPresent 20 >5.7 .75 (.51-.89) <.001 23>5.7 .70 (.48-.85) <.001
Absent 1801.3 .28 (.20-.37) 229 1.8 .27 (.20-.35)
FAB L1 79 1.9 .37 (.25-.50) .12 99 2.2.36 (.25-.47) .11
L2 110 1.1.29 (.15-.41) 134 1.4 .27 (.18-.37)
Immunophenotype T/TMy 39 >3.8 .56 (.38-.73).01 48 >3.2 .50 (.34-.65) .004
B/BMy126 1.3 .27 (.17-.38) 159 1.5.26 (.18-.36)
Cytogenetic group4-150 Normal 65 2.3.38 (.26-.53) <.001 79 2.9 .37 (.26-.50)<.001
Miscellaneous 64 4.1 .52 (.37-.67)82 3.0 .49 (.35-.62)
Unfavorable 750.8 .11 (.04-.25) 95 1.2 .12 (.06-.25)
Treatment protocol 8811, 9111, 9311 162 1.7.35 (.26-.45) .06 189 1.9 .35 (.27-.44) .06
8011, 8411, 8513 42 0.9 .21 (.11-.37) 671.7 .19 (.11-.30)
  • Abbreviations: CI, confidence interval; FAB, French-American-British classification; N, number of patients.

  • F4-150 Unfavorable consists of patients with t(9;22), t(4;11), −7, or +8 abnormalities; miscellaneous group consists of all other abnormalities.