Table 1.

Expression of HLA Class I, TAP 1, and TAP 2 in H-RS Cells

HD Case Subtype EBV Status HLA Class I TAP 1 TAP 2
EBER in situ Hybridization LMP 1 Staining
1 MC + ++++ ++ ++
2 MC + + +++ ++ ++
3 MC + + + + +
4 MC + ++++ +++ +++
5 MC + + ++ + ++
6 MC + + ++ ++ ++
7 NS + +++ ++ ++
8 NS + + ++ ++ ++
9 NS + + ++ ++ +
10 NS + +++ ++ +
11 NS + + ++ ++ ++
12 NS + + ++ ++ ++
13 NS ++ + + ++
14 NS + + ++ ++ +
15 NS + + ++ + ++
16 NS + ++ +++ ++
17 NS + + + +/−
18 NS + + ++ +/−
19 NS ++ ++ ++
20 NS + + ++++
21 LP + + +/− +++ +
22 LP+ + ++ ++
23 IF + + ++++ ++
24 IF + + ++ ++ ++
25MC ++ ++ ++
26 MC +/− +++ +++
27 NS ++++ +++
28 NS +++ ++
29 NS +++ ++
30 NS++ ++
31 NS ++ ++
32 NS ++++
33 NS ++ ++
34LP +/− ++ ++
35 LP +++ +++
36 LP +/− ++
37 ni + + +
38ni + ++ ++
  • Abbreviations: MC, mixed cellularity; NS, nodular sclerosing; LP, lymphocyte predominant; IF, interfollicular HD; ni, not interpretable; −, no staining; +/−, only some cells positive; +, weak staining; ++, medium staining; +++, strong staining.