Table 5.

Multiplex RT-PCR and Cytogenetic Data on 62 Pediatric ALL Patients

UPN Status Diagnose Sex Age (yr) SampleMultiplex RT-PCR Karyotype
A
  41 RelapseT-ALL M 22 PB t(9;22)(q34;q11)46,XY[1]/46-47,XY,del(7)(q11q21),+8,der(11)t(11;14)(p14;q21),14, +21,del(21)(q21)[cp.8]
  89 Presen. Pre-B-ALLM 2.9 PB dupMLL(11q23)53,XY,+X,+4,+6,+8,+14,+17,+18,+21[co.5]
  90 Relapse Pre-B-ALL M 9 PBt(9;22)(q34;q11) 46,XY[2]/46,XY,del(12)(p11.1p12.1)[3]
  91 Presen. Pre-B-ALL M 3.3 BMt(9;22)(q34;q11) 46,XY[10]
  94 RelapsePre-B-ALL M 3.0 PB t(9;22)(q34;q11)46,XY[4]/46,XY,t(9;22)(q34;q11)[6]
  97 Remis.Pre-B-ALL M 3.4 PB dupMLL(11q23)53-54,XY,+X,+Y,add(5p),+8,add(8p),+10,+14,+21[co.6]
  99 Presen. Pre-B-ALL F 0.6 PBt(10;11)(p12;q23) 46,XX,add(21)(q?22)[1]
 101Presen. Pre-B-ALL M 3.9 PBdupMLL(11q23) 46,XY[10]
 103 RelapsePre-B-ALL M 21 BM dupMLL(11q23)46-47,XY,del(1)(q25),del(8)(q?21.1q?22),del(10)(q24),+20,+21, [c.10]
 108 Remis. Pre-B-ALL M 9 BMdupMLL(11q23) 46,XY[5]
 109 Presen.Pre-B-ALL M 2.7 PB t(12;21)(p13;q22)Failed
 111 Presen. Pre-B-ALL M 2.4PB dupMLL(11q23) 46,XY[5]
 229Presen. Pre-B-ALL F 9 BM t(12;21)(p13;q22)46,X,del(X)(q?25)[3]
 234 Presen. Pre-B-ALLM 5 PB t(4;11)(q21;q23)50-51,XY,+Y,+8,+21,+22[cp.3]
?
 243Presen. T-ALL M 1.0 PB t(11;19)(q23;p13.3)46,XY,ins(1)(q21;?)[16]/46,XY,idem,t(14;?)(q11;?)[3]/48,XY, ins(1)(q21;?),+8,+8[3]
 253 Presen. Pre-B-ALL M3.4 PB t(1;19)(q23;p13) Failed
 254Presen. Pre-B-ALL F 4.6 PB t(12;21)(p13;q22)Failed
 256 Presen. Pre-B-ALL F 2.6PB t(1;19)(q23;p13)46,XY[3]/47,XY,−1,+1p-,+1q-[1]
 257 Remis.Pre-B-ALL M 3.3 BM t(1;19)(q23;p13)46,XY[10]
 262 Remis. Pre-B-ALL F 7BM t(6;11)(q27;q23) 46,XX[7]/46,XX,del(6)(q24)[3]
 264 Presen. Pre-B-ALL M 13 BMt(6;11)(q27;q23) Failed
 265 Remis. Pre-B-ALLF 6 BM t(11;19)(q23;p13.1) 46,XX[10]
B
  93 Presen. Pre-B-ALL M 2.5 PBt(16;21)(p11;q22) ND
 106 Presen. T-ALL F10 BM dupMLL(11q23) ND
 112Presen. ALL M 10 BM dupMLL(11q23)ND
 227 Presen. ALL F 14 PBt(11;19)(q23;p13.1) ND
 238 Presen. Pre-B-ALLF 10 BM t(12;21)(p13;q22) ND
 259Remis. Pre-B-ALL F 5 BM t(6;11)(q27;q23)ND
C
  95 Presen. Pre-B-ALL M 8PB NAD 46,XY[10]
  96 Presen.Pre-B-ALL F 3.9 PB NAD 46,XX[4]
  98 Relapse ALL M 14 PB NAD46,XY[4]
 102 Presen. T-ALL M 5 PBNAD 46,XY[10]
 110 Presen. Pre-B-ALL M5 BM NAD 46,XY[1]/46,XY,−9,+14,add(14q)[4]
 230 Presen. Pre-B-ALL F 1.5 PB NAD46,XX[10]
 235 Presen. Pre-B-ALL M 5PB NAD46,XY[3]/44-45,XY,3p-,t(4;6)(p16;q?25),−7,−9[cp.3]
 237 Presen. T-ALL F 6 BM NAD46,XX[4]/46,XX,del(6)(q26)[4]/46,XX,del(16)(q23)[2]
 239 Presen. Pre-B-ALL M 2.5 PB NAD46,XY[4]
 241 Presen. Pre-B-ALL M 4.3BM NAD Failed
 242 Presen. Pre-B-ALLM 7 PB NAD Failed
 244 Presen.Pre-B-ALL F 4.3 PB Ins. N/Q cells46,XX[10]
 245 Presen. Pre-B-ALL M 4.7PB Ins. N/Q cells 47,XY,+21[4]/48,XY,+21,+r[2]
 248 Remis. Pre-B-ALL F 5 BM Ins. N/Q cells 46,XX[1]
 249 Presen. Pro-B-ALL M5 PB NAD 46,XY[9]
 250 Presen.T-ALL M 5 BM NAD Failed
 251Presen. Pre-B-ALL M 2.0 PB NAD46,XY[10]
 252 Relapse Pre-B-ALL F 12BM Ins. N/Q cells Failed
 255 Presen.Pre-B-ALL M 5 PB NAD Failed
 258Presen. Pre-B-ALL F 5 PB NAD46,XX[1]/47,XX,+21[3]
 260 Presen. Pre-B-ALLM 3.7 BM Ins. N/Q cells Failed
 261Presen. Pre-B-ALL M 4.3 BM NAD Failed
 263 Presen. Pre-B-ALL F 6 BM NAD46,XX[6]
D
  88 Presen. Pre-B-ALLF 4.8 PB NAD ND
  92 Remis.Pre-B-ALL M 7 BM NAD ND
 100Relapse Pre-B-ALL M 14 PB NAD ND
 107 Presen. Pre-B-ALL F 6 PB NADND
 228 Presen. Pre-B-ALL M 3.3 PBNAD ND
 231 Presen. Pre-B-ALL F 7PB NAD ND
 232 Presen. Pre-B-ALL M2.2 BM NAD ND
 236 Presen. Pre-B-ALLF 3.2 PB NAD ND
 246 RelapsePre-B-ALL F 5 BM NAD ND
 247Presen. Pre-B-ALL M 1.7 PB Ins. N/Q cellsND
 320 Presen. Pre-B-ALL F 2.7 BMNAD ND
  • (A) PCR-positive patients with cytogenetic data; (B) PCR-positive patients with no cytogenetic data; (C) PCR-negative patients with cytogenetic data; (D) PCR-negative patients with no cytogenetic data. Cytogenetically t(9;22)(q34;q11)[10] at diagnosis. Abbreviations and notes are as in Table 4.