Table 4.

Incidence of Tumor Growth and Regression in Athymic Mice Injected With an LMP1-Transfected BL41 Cell Line

BL41 Cell Line LMP1 Status Tumors/ Mice Injected Days to Tumor Appearance Days to Tumor Regression Regressing Tumors % RegressionMaximum Size (cm2)
Parental 8/8 11 ± 4.7 0/8  0
GTP 6/6 11 ± 7.1 57 1/6 17 7.2
LMP1 +6/6 20 ± 6.9 72 ± 24 4/6 674.4 ± 1.8
GTP + LMP1 −/+ 6/6 9.0 ± 3.350 ± 0.0 3/6 50 8.2 ± 0.9
  • BL41 cells, vector only–transfected and LMP1-transfected BL41 cells (107) were inoculated subcutaneously into athymic BALB/c mice. A group of six mice was injected in the same subcutaneous site with equal numbers (107) of vector-transfected and LMP1-transfected BL41 cells. Experimental conditions and evaluation are described in the legend to Table 1.