Table 3.

Binding of Human IgG Subclasses of NK Cells From Individuals Genotyped for FcγRIIIA Polymorphisms (MFI ± SD)

GenotypeSubclass
FcγRIIIA-48FcγRIIIA-158IgG1IgG2IgG3IgG4Cytophilic IgG
48LL 158FF  913 ± 31758 ± 33 390 ± 131106 ± 104 337 ± 159
48LL 158VF 1,257 ± 608124 ± 126 912 ± 2863-150 413 ± 178 695 ± 405
48LR or 48LH 158VF 1,243 ± 194155 ± 133 746 ± 230548 ± 2021,139 ± 542
48LR or 48LH 158VV 1,814 ± 5073-151 173 ± 981,053 ± 487487 ± 2861,788 ± 796
  • At least three donors of each genotype were tested. Data were analyzed with the Student's t-test and the Welch's approximate t-test. P values below .05 were considered significant.

  • F3-150 Statistically significant difference from IgG3 binding by NK cells from FcγRIIIa-158F/F individuals of the same FcγRIIIA-48 genotype.

  • F3-151 Significantly different from FcγRIIIa-158V/F cells of the same FcγRIIIA-48 genotype.