Table 2.

CD16 MoAb Binding (mean fluorescence intensities ± SD) of NK Cells From Individuals Genotyped for FcγRIIIA Polymorphisms

GenotypeMoAb
FcγRIIIA-48FcγRIIIA-158Control mIgG2aCLBFcRgran1MEM154B73.1
48LL 158FF 12 ± 61,539 ± 25742 ± 20303 ± 176
48LL 158VF 8 ± 41,713 ± 719460 ± 218* 248 ± 105
48LR or 48LH 158VF 6 ± 21,443 ± 504323 ± 182121 ± 51
48LR or 48LH 158VV 10 ± 51,102 ± 298718 ± 341 151 ± 117
48HH ρ 158VV 71,69489255
48RR 2-155 158VV 151,443642103
  • At least three donors of each genotype were tested. Data were analyzed with the Student's t-test the and Welch's approximate t-test. P values below .05 were considered significant.

  • * Statistically significant difference from mean fluorescence intensity of NK cells from FcγRIIIa-158FF individuals of the same FcγRIIIA-48 genotype.

  • Significantly different from FcγRIIIa-48LL NK cells of the same FcγRIIIA-158 genotype.

  • Significantly different from FcγRIIIa-158VF NK cells of the same FcγRIIIA-48 genotype.

  • ρ Two individuals were tested; one healthy control and one patient suffering from recurrent viral infections.

  • F2-155 One healthy individual was tested.