Table 4.

Pharmacokinetic Parameters After Intravenous Drip of As2O3 in Relapsed APL Patients

Patient No.Cpmax (μmol/L)t1/2αt1/2βVc (L)CL(s) (L/h)AUC (μmol/h/L)
(h)(h)
66.010.556.383.831.3836.20
64-150 6.281.0513.614.331.2938.70
88.181.0116.662.931.3443.95
84-151 6.220.8711.263.821.4035.70
97.700.4912.363.441.2739.55
94-150 6.080.828.023.811.7029.40
106.621.1511.654.101.5332.60
104-150 6.221.0010.034.311.4934.30
116.820.6210.463.981.4334.85
125.540.9311.174.301.8127.60
136.621.1616.524.151.3337.55
134-151 6.891.429.564.941.4434.75
157.301.2111.863.891.3337.70
  • F4-150 On day 30 of remission induction.

  • F4-151 On day 1 of consolidation treatment.