Table 5

Comparative stroke risk in different cohorts

CSSCDJamaicaDallasLondon, United KingdomCréteil, France
Blood 1998J Pediatr 1992Blood 2004Haematologica 2007Newborn Cohort
Infant CohortNewborn CohortNewborn CohortNewborn Cohort
Enrollment period1978-19881983-20021983-20051988-2007
SS patientsSS patientsSS/Sb0 patientsSS patientsSS/Sb0 patients
Number of patients included in the cohort2436310448180217
Patient-years of follow-up1781357115421609
Number of first strokes before age 20 years51173073
First stroke incidence/100 patient-years0.61
    Up to 16 years0.3 (95% CI 0.1-0.8)
    Up to 18 years0.850.19 (95% CI 0.04-0.5)
KM estimate of stroke risk by age
    43.7% (95% CI 1.7%-5.7%)
    50.7% (95% CI 0.1%-5.0%)1.9% (95% CI 0.6%-5.9%).
    65.7% (95% CI 3.3%-8.2%)
    108.4% (95% CI 5.5%-11.6%)2.7% (95% CI 0.9%-8.3%)1.9% (95% CI 0.6%-5.9%).
    147.8%11.5% (95% CI 7.3%-15.7%)1.9% (95% CI 0.6%-5.9%).
    154.3% (95% CI 1.5%-11.4%)
    1811.5% (95% CI 7.3%-15.7%)1.9% (95% CI 0.6%-5.9%).
    2011%12.8% (95% CI 4.8%-31.3%)
  • CI indicates confidence interval; and CSSCD, Cooperative Study of Sickle Cell Disease.