Table 4

Blood parameters in 54 patients before and after HU therapy

Before HU°On HU°°P
Mean (SD)Mean (SD)
Age, y6.4 (3.6)9.5 (4.0)
WBC count, ×109/L14.6 (5.8)9.1 (3.8)<.001
Neutrophil count, ×109/L7.3 (4.2)4.6 (3.3)<.001
Platelet count, ×109/L405.6 (118.9)320.1 (99.4)<.001
Hemoglobin level, g/dL7.5 (0.9)8.7 (1.1)<.001
Hematocrit, %22.4 (3.0)26.0 (3.5)<.001
MCV, flt80.4 (9.5)97.6 (13.7)<.001
Reticulocyte count, ×109/L303.4 (99.9)183.5 (86.8)<.001
HbF, %8.5 (5.0)16.4 (8.4)<.001
LDH, IU/L1090 (361)801 (313)<.001
Total bilirubin, μmol/L53.9 (38.4)42.1 (25.9).068
  • HbF indicates fetal hemoglobin; HR, hazard ratio; LDH, lactate dehydrogenase; MCV, mean corpuscular volume; and WBC, white blood cell count.