Table 4

Clonal chromosome abnormalities detected in NPM1-mutated AML and other AML with recurrent cytogenetic abnormalities

KaryotypeAML
NPM1 mutation (n = 689)t(8;21) (n = 100)inv(16) (n = 73)t(15;17) (n = 147)11q23/MLL (n = 79)
Additional abnormalities105/689 (15.2%)71/100 (71.0%)24/73 (32.9%)61/147 (41.5%)37/80 (46.2%)
−X/−Y1848341
+4112002
−730000
+8435112115
+1321102
+1901005
+2150207
+22101302
del(7q)12340
del(9q)917051
del(11q)02000
ider(17)(q10)t(15;17)000100
Other671594840
  • This table is an update of the findings reported by Haferlach et al.84