Table 3

High macrophage turnover in mesenteric lymph node of SIV-infected (AIDS) monkey

Animal/areaTotalCD163+ cells (macrophage)
BrdU+TUNEL+TotalBrdU+TUNEL+TUNEL+BrdU+
Uninfected (3.0%)*
    Sinus73.8 ± 26.66.6 ± 2.340.8 ± 2.92.0 ± 1.60.4 ± 0.50
    Follicle90.8 ± 25.17.4 ± 3.937.0 ± 18.42.0 ± 1.40.4 ± 0.50.2 ± 0.4
Infected (45.3%)
    Sinus189.0 ± 25.127.6 ± 7.8194.6 ± 11.033.6 ± 3.511.0 ± 1.42.0 ± 1.0
    Follicle169.2 ± 87.533.8 ± 11.9162.4 ± 43.227.0 ± 7.010.2 ± 1.81.0 ± 0.7
P
    Sinus.0001.0004< .0001< .0001< .0001na§
    Follicle.0904.0015.0003< .0001< .0001.0650
  • * Percentages of BrdU+ monocytes in blood are indicated.

  • Data were analyzed for statistical significance by the unpaired t test.

  • Each value represents mean ± SD of the cell number per area obtained from 5 randomly selected areas.

  • § na indicates not applicable.

  • Not significant (P > .05).