Table 1

Gene ontology (GO) terms represented among BCL6 target genes

GC-specific genesCommon genesDLBCL-specific genesGO term
3 (0)*2 (1)1 (1)GO:0043038 amino acid activation
3 (0)*2 (1)1 (1)GO:0006418 tRNA aminoacylation for protein translation
3 (0)*2 (1)4 (1)GO:0006399 tRNA metabolic process
6 (1)*5 (3)9 (4)GO:0034660 ncRNA metabolic process
3 (0)*2 (1)1 (1)GO:0043039 tRNA aminoacylation
0 (0)3 (0)*0 (0)GO:0045739 positive regulation of DNA repair
0 (0)4 (1)*1 (1)GO:0006282 regulation of DNA repair
4 (2)16 (7)*12 (8)GO:0006511 ubiquitin-dependent protein catabolic process
4 (2)17 (8)*12 (9)GO:0030163 protein catabolic process
4 (2)16 (7)*12 (8)GO:0044257 cellular protein catabolic process
8 (4)22 (13)*24 (15)GO:0043285 biopolymer catabolic process
4 (2)16 (7)*12 (8)GO:0043632 modification-dependent macromolecule catabolic process
4 (2)16 (7)*12 (8)GO:0051603 proteolysis involved in cellular protein catabolic process
3 (2)13 (5)*8 (6)GO:0051438 regulation of ubiquitin-protein ligase activity
3 (2)13 (5)*8 (6)GO:0051340 regulation of ligase activity
3 (1)11 (4)*8 (5)GO:0051436 negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle
0 (0)4 (1)*3 (1)GO:0009303 rRNA transcription
0 (0)1 (1)7 (2)*GO:0000910 cytokinesis
0 (0)1 (1)7 (2)*GO:0051301 cell division
6 (3)12 (10)25 (12)*GO:0022403 cell cycle phase
3 (1)8 (4)13 (5)*GO:0007050 cell cycle arrest
3 (1)7 (3)10 (4)*GO:0007067 mitosis
3 (1)8 (4)10 (4)*GO:0000087 M phase of mitotic cell cycle
5 (2)10 (7)18 (8)*GO:0000279 M phase
6 (4)20 (12)26 (14)*GO:0000278 mitotic cell cycle
8 (4)20 (12)30 (14)*GO:0034984 cellular response to DNA damage stimulus
9 (5)24 (15)33 (17)*GO:0051716 cellular response to stimulus
8 (4)22 (14)32 (16)*GO:0033554 cellular response to stress
10 (4)20 (14)28 (16)*GO:0006366 transcription from RNA polymerase II promoter
6 (2)10 (7)18 (8)*GO:0006414 translational elongation
0 (0)0 (0)3 (0)*GO:0018211 peptidyl-tryptophan modification
0 (0)0 (0)3 (0)*GO:0018317 protein amino acid C-linked glycosylation via tryptophan
0 (0)0 (0)3 (0)*GO:0018406 protein amino acid C-linked glycosylation via 2′-alpha-mannosyl-L-tryptophan
0 (0)0 (0)3 (0)*GO:0035269 protein amino acid O-linked mannosylation
0 (0)0 (0)3 (0)*GO:0035268 protein amino acid mannosylation
2 (0)1 (1)4 (1)*GO:0043631 RNA polyadenylation
5 (3)16 (11)26 (13)*GO:0034622 cellular macromolecular complex assembly
9 (4)23 (14)30 (16)*GO:0044265 cellular macromolecule catabolic process
5 (4)18 (12)26 (14)*GO:0034621 cellular macromolecular complex subunit organization
11 (7)27 (21)39 (24)*GO:0022607 cellular component assembly
11 (7)30 (21)39 (25)*GO:0043933 macromolecular complex subunit organization
11 (6)27 (20)39 (23)*GO:0065003 macromolecular complex assembly
2 (0)0 (2)7 (2)*GO:0045333 cellular respiration
0 (1)5 (2)7 (2)*GO:0006730 one-carbon compound metabolic process
9 (7)25 (21)45 (24)*GO:0006996 organelle organization
  • The first 3 columns list the number of targets per GO term present among GC-specific, in common between GC and DLBCL and DLBCL-specific genes. The values in parentheses denote the expected number of genes per GO term for each category (ie, GC, common, DLBCL).

  • * The numbers show significant enrichment versus expected (as demonstrated in the heatmap color code in Figure 1A).

  • The numbers are nonsignificant.