Table 3

All adverse reactions reported by patients on study

Adverse reactionPatients reporting reaction, nReaction probably related to R788
Drowsiness/fatigue7No
Diarrhea6Yes
SBP increased by > 10 mm Hg5Yes
Nausea4Yes
Headache4Yes
Weight gain > 5 kg3Yes
Vomiting3Yes
Abdominal pain3Yes
Shortness of breath3No
Dizziness2No
Constipation2Yes
ALT > 2× ULN2Yes
UTI1No
DVT1No
Chest tightness1No
Fever1No
Blurry vision1No
Lung hemangioma1No
LAD1No
  • SBP indicates systolic blood pressure; ALT, alanine aminotransferase; ULN, upper limit of normal; UTI, urinary tract infection; DVT, deep vein thrombosis; and LAD, lymphadenopathy.