Table 2

EZH2 target gene enrichment in miR-26a-induced gene expression pattern

Gene symbolDescriptionProbe setGeometric mean of intensities (class empty/class miR-26a)Fold change after PcG knock-down*
ARHGAP24Rho GTPase-activating protein 241566825_at0.70372921.5
ATAD2ATPase family, AAA domain containing 2222740_at1.3870516−1.9
CCNB1Cyclin B1214710_s_at1.3400383−1.5
CCNE2Cyclin E2205034_at1.5680341−2.5
CDC25ACell division cycle 25 homolog A (S. cerevisiae)1555772_a_at1.3642922−1.9
CDC6Cell division cycle 6 homolog (S. cerevisiae)203968_s_at1.4108894−3.1
CDT1Chromatin licensing and DNA replication factor 1228868_x_at1.5277866−2.2
CHAF1AChromatin assembly factor 1, subunit A (p150)203976_s_at1.5635639−6.2
CUGBP2CUG triplet repeat, RNA binding protein 2242268_at0.71931291.7
DCC1defective in sister chromatid cohesion homolog 1 (S. cerevisiae)219000_s_at1.3318879−1.6
GMNNGeminin, DNA replication inhibitor218350_s_at1.3320183−2
GTSE1G2- and S-phase expressed 1215942_s_at1.4042593−3.4
HELLSHelicase, lymphoid-specific220085_at1.3691602−2.3
LRAPLeukocyte-derived arginine aminopeptidase240338_at0.6309561.4
MCM10MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)220651_s_at1.4244193−3.1
MCM4MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)222037_at1.2871303−4.8
MKI67Antigen identified by monoclonal antibody Ki-67212022_s_at1.4520355−2.7
MYBL1v-myb myeloblastosis viral oncogene homolog (avian)-like 1213906_at1.5254951−1.7
ORC1LOrigin recognition complex, subunit 1-like (yeast)205085_at1.511178−2.9
PDE4DIPPhosphodiesterase 4D interacting protein (myomegalin)232615_at0.76586411.1
RFC4Replication factor C (activator 1) 4, 37kDa204023_at1.4484428−1.9
SKP2S-phase kinase-associated protein 2 (p45)210567_s_at1.4732182−2.2
SLC17A5Solute carrier family 17 (anion/sugar transporter), member 5221041_s_at0.77744431.3
SOX5SRY (sex determining region Y)-box 5215768_at0.6858781.7
TncRNATrophoblast-derived noncoding RNA238320_at0.54576271.9
ZBTB1Zinc finger and BTB domain containing 11557036_at0.74101044.9
ZBTB10zinc finger and BTB domain containing 10222863_at0.73214632.6
  • * Bracken et al.34