Table 2

The HLA-G–related regulatory cells

NameGenerationPhenotypeHLA-G inductionHLA-G expressionMechanism of actionReference
Regulatory T cells
    HLA-G–induced TregPeripheryNone known/CD3+CD4low and CD3+CD8lowAPC-HLA-G1+ or HLA-G5NoUnknown/soluble factors including IL-1082/55, 57
    HLA-G+ TregsThymusCD3+HLA-G1+NoHLA-G1 and HLA-G5Soluble factors including HLA-G83
    HLA-G1acq+ T cellsPeripheryCD3+HLA-G1+Trogocytic HLA-G1 acquisitionHLA-G1HLA-G138
    CD4+CD25+CTLA4+/CD8+CD28PeripheryCD4+CD25+/CD8+CD28-HLA-G–modified DCNo—/possibly IL-1040
Tolerogenic APC
    HLA-G1+ APCPeripheryHLA-G1+NoHLA-G1HLA-G182
    HLA-G–modified DCPeripheryHLA-DRlow, CD80low, CD86lowHLA-G tetramersNo40
Suppressive NK cells: HLA-Gacq+ NK cellsPeripheryCD16+HLA-G1+Trogocytic HLA-G1 acquisitionHLA-G1HLA-G139
  • — indicates not applicable.