Table 4.

Engraftment of CD33+ and CD33- fractions of AML in NOD/SCID mice

Sample no. and dose/mouseNo. mice with AML/no. mice injected
CD33+ fraction
   1
      1.0 × 106 2/5
      3.0 × 106 0/2
      6.0-10.0 × 106 6/8
   2
      1.0 × 106 2/3
      6.0 × 106 2/2
   3
      4.0 × 105 1/3
      1.0 × 106 3/3
      1.0 × 107 2/2
   4*
      1.6 × 105 2/3
      1.0 × 107 2/3
   5*
      5.9 × 105 0/2
      8.4 × 106 1/1
   6
      1.5 × 106 2/3
   7
      5.0 × 106 0/1
      2.0 × 106 0/4
   8
      2.4 × 106 2/3
   9
      3.8 × 106 3/3
   10
      2.1 × 106 0/3
      7.0 × 106 1/1
   11*
      3.5 × 105 2/4
   12*
      2.0 × 106 4/4
CD33- fraction
   1
      1.0 × 106 0/5
      3.0 × 106 0/3
   2
      1.0 × 106 0/3
   3
      4.0 × 105 0/3
   4*
      1.6 × 105 0/3
   5*
      5.9 × 105 0/3
   6
      1.5 × 106 0/3
   7
      7.9 × 105 1/3
      2.0 × 106 0/5
   8
      1.0 × 105 0/3
   9
      3.8 × 106 0/3
   10
      2.1 × 106 0/3
   11*
      1.2 × 104 0/2
   12*
      8.0 × 103 0/2
  • * NOD/SCID-β2m-/- mice were used as hosts for these AML samples

  • Lin-CD34+CD38- cells from these samples were sorted into CD33+ and CD33- fractions