Table 6.

Autologous T-cell proliferation in the presence of MVA-TRICOM–infected CLL cells

Patient, stimulator cellsAutologous stimulation index
2
   Uninfected 1.0
   MVA-WT 0.5
   MVA-TRICOM 34.8
8
   Uninfected 1.3
   MVA-WT 1.6
   MVA-TRICOM 30.6
16
   Uninfected 1.7
   MVA-WT 1.3
   MVA-TRICOM 27.2
13
   Uninfected 1.1
   MVA-WT 1.0
   MVA-TRICOM 13.4
14
   Uninfected 1.3
   MVA-WT 0.7
   MVA-TRICOM 5.3
12
   Uninfected 1.1
   MVA-WT 1.3
   MVA-TRICOM 4.2
19
   Uninfected 1.7
   MVA-WT 1.3
   MVA-TRICOM 2.3
10
   Uninfected 0.7
   MVA-WT NA
   MVA-TRICOM 2.2
18
   Uninfected 1.0
   MVA-WT 1.1
   MVA-TRICOM 1.9
17
   Uninfected 1.1
   MVA-WT 1.3
   MVA-TRICOM 1.4
  • CD3+ T cells from patients with CLL were stimulated with uninfected, MVA-WT-, or MVA-TRICOM–infected CLL cells, at a ratio of stimulator to effector cells equal to 1:2.5. Proliferation was measured as 3H-thymidine incorporation on day 5 of culture. Stimulation index was calculated as cpm (T cells + CLL cells)/cpm (T cells alone).

    NA indicates not available.