Table 6.

Examples of active agents targeting signaling pathways downstream of BCR-ABL

TargetCompoundActivity in imatinib-resistant cellsClinical trialsReference no.
Farnesyl transferase Lonafarnib Tipifamib Yes Yes 136-139
MEK1 PD98059 Yes No 140
RAF-1 BAY43-9006 Yes Yes 141
PI3 kinase LY294002 Wortmannin Yes No 142
mTOR Rapamycin Yes Yes 143,144
Cyclin-dependent kinases Favopiridol Yes Yes 145