Table 2.

DLBCL consensus cluster signatures

FunctionGene
OxPhos cluster
    NADH dehydrogenase complex NADH dehydrogenase (ubiquinone) 1:α/β subcomplex 1, 8 kDa; β subcomplex 1, 7 kDa; β subcomplex 2, 8 kDa Ubiquinol-cytochrome c reductase hinge protein
    Cytochrome c/cytochrome oxidase (COX) complex Cytochrome c COX 5b, 6a1, 7a2L, 7b, 7c, 11
    ATP synthase, mitochrondrial F0 complex, subunit c
F1 complex β polypeptide, γ polypeptide 1 and O subunit
    ATP other ATP binding protein
ATP binding cassette subfamily D (ALD, member 3)
ATPase H+ transporting, lysosomal: 21 kDa, VO subunit c and 9 kDa
    Other, mitochondrial Translocases of inner mitochondrial membrane (TIMM): nos. 8B and 23
Translocases of outer mitochondrial membrane (TOMM): nos. 7 and 20
Diazepam binding inhibitor
    Apoptosis BFL-1/A1
MIHC (BIRC3)
TNFA1P8 (SCC-S2)
TNFRSF6 (FAS)
Apoptosis-related protein (APR-3)
    Proteosome Proteosome subunits: α types 2, 5, 6, and 7; and β type 4
Proteosome 26s subunits: ATPase 2 and non-ATPase 4
    Ribosome, mitochondrial L3, L15, L39, S17, S31, and S36
    Ribosome, other L3, L4, L5, L10, L13a, L15, L17, L27, L30, L31, L36A, L36, large PO, S12, S17, S20, and S21
    Other X-ray repair complementing defective repair 5 (XRCC5)
Superoxide dismutase 1 (SOD1)
Jumping translocation breakpoint
CDW52
H2AZ
PTEN
BCR/proliferation cluster
    BCR signaling cascade CD22
CD19
Igμ
CD79a
BLK
SYK
PLC γ 2
Inositol 1, 4, 5 triphosphate receptor type 3
Inositol 1, 4, 5 triphosphate 3 kinase B
Inositol polyphosphate-5-phosphatase 145 kDa
MAP4K1
    Class II molecules CD74 (invariant polypeptide MHC class II)
    Transcription factors PAX5
FOXO1A
BCL6
POU2AF1 (BOB-1/OBF-1/OCAB)
STAT6
TCF3 (E2A)
NFAT
SPI-B
ETS-1 (E26 homolog)
Ikaros
MYC
    Other B-cell markers CD37
BC11A
    Proliferation KI67
CDK2
Signal-induced proliferation-associated 1 like 3
    Replication/repair DEAD/H box polypeptides 11 and 39
Postmeiotic segregation increased (PMS) 2-like 2, 6, and 9
Minichromosome maintenance deficient (MCM) 2, 4, 5, and 7
p53
H2AX
PAX transactivation domain-interacting protein (PTIP)
MUTL homolog 6
    Motility/cytoskeletal Villin 2 (Ezrin)
    Transcription modulators SMARC A4, B1, and F1
    Posttranscriptional modification HDAC1
MYST histone acetyltransferase 4
Ubiquitin-activating enzyme E1
    Other Heat shock protein 90 beta
Host response cluster
    T/NK cell T-cell receptor α and β
CD2
CD3 δ, ϵ and γ
CD6
CD28
GATA3
cMAF
CXCR6
LST (NKp30)
Zap70
Linker for activation of T-cells (LAT)
FYN
FYN binding protein (SLAP)
Lymphocyte activation gene 3 (LAG3)*
CD100 (Sema 4D)
Perforin
NK transcript 4*
T-cell immune regulator (TIRC7)
Leukocyte-associated Ig-like receptor 1 (LAIR-1)
    Complement Complement 1qB, 1S, and 4A
Complement 3α receptor
Clade G (C1 inhibitor)
    Monocyte/macrophage CD14*
CD163
B lymphocyte activator, macrophage expressed (BLAME)
FGR
SHPS-1 (BIT/SIRPα)
Granulin
Allograft inflammatory factor
    Antigen processing Lysosomal-associated membrane protein 1 (LAMP1)*
Cathepsins B and D
IFN—γ inducible protein 30 (GILT)*
    Interferon (IFN) IFN-induced transmembrane proteins 1 and 2
Guanylate binding proteins 1** and 2, IFN-inducible
STAT1*
Interferon regulatory factors (IRFs) 1 and 7
    MHC Class I HLA A, C, E and F
    TNF family members TNFRSF 1A and B
TNFSF10 (TRAIL)
TNFSF13 (APRIL)*
    Cytokine receptors IL 2 receptor γ
IL 6 receptor
IL 15 receptor α*
TGF β receptor II
CSF-1 receptor*
    ECM/adhesion LFA-1 (integrins α L and β 2)*
PECAM1 (CD31)
P-selectin glycoprotein ligand (PSGL-1)
Collagens: type XVIII α 1 and type IV α 2
Stromal-derived factor 1
    Apoptosis Caspase 4, apoptosis-related cysteine protease*
    Other Notch 2
Disabled homolog 2 (DAB2)
FOXO3A
MAF B
Prostaglandin E receptor 4
S100A4
  • Gene lists derived from the top 250 genes with higher levels of expression in the indicated consensus cluster.

  • * Genes included in previously described LN signature.5