Table 1.

Gene set enrichment analysis of the DLBCL consensus clusters

Ox PhosBCR/proliferationHost response
KSMHT PKSMHT PKSMHT P
Mitochondrial pathways
    PGC 130.9 .004 13.2 .763 3.8 .931
    VOXPHOS 156.1 .001 13.3 .760 2.9 .948
    Human mito DB 152.6 .002 11.8 .790 0.6 .987
    Mitochondrial 157.5 .001 16.2 .703 0.4 .991
    OXPHOS 141.0 .003 13.7 .753 2.9 .946
Gen MAPP
    Electron transport 148.1 .000 14.4 .641 3.1 .839
    Cell cycle 33.4 .298 104.8 .004 0.8 .873
    Complement activation-classical 11.9 .685 7.4 .766 105.9 .004
Bio Carta
    Complement 12.0 .745 6.4 .846 91.7 .004
    T cytotoxic 8.5 .809 7.0 .835 113.5 .000
    T helper 8.5 .809 7.0 .835 113.5 .000
    T ob 1 27.0 .440 2.8 .902 103.2 .002
Coregulated gene sets
    C7 26.2 .494 7.4 .870 164.6 .001
    C10 130.5 .004 1.4 .98 19.7 .62
Additional DLBCL gene sets
    Proliferation 120.4 .103 142.0 .064 3.1 .854
    Lymph node 24.3 .577 1.7 .902 279.7 .000
  • GSEA was performed using gene sets from (1) Biocarta; (2) GenMapp; and (3) a series of manually curated pathways involved in mitrochondrial function and metabolism (Mitrochondrial pathways).15 Additional coregulated gene sets from normal murine tissues (Coregulated gene sets)15 and DLBCLs (DLBCL gene sets)5 were also used. KS indicates Kolmogorov-Smirnoff score, and MHT P connotes a P value corrected for multiple hypothesis testing.