Table 2.

Analysis of selected cytokines and coagulation factors in groups of mice (n = 5)

Cytokine/coagulation factorUninfectedRat IgG, day 4Anti-CD41, day 4P, rat IgG vs α-CD41
IL-10, pg/mL 135 ± 10 166 ± 26 386 ± 72 .005
IL-2, pg/mL 1 ± 1 30 ± 8 5 ± 3 .002
IL-1α, pg/mL 29 ± 4 53 ± 12 110 ± 27 .03
IFN-γ, pg/mL 1 ± 1 25 ± 15 84 ± 18 .01
TNF-α, pg/mL 0 ± 0 7 ± 7 62 ± 19 .01
IL-6, pg/mL 0 ± 0 3 ± 3 33 ± 9 .003
Fibrinogen, μg/mL 3156 ± 339 3363 ± 147 4560 ± 337 .03
fVII, ng/mL 0.70 ± 0.05 0.60 ± 0.05 0.64 ± 0.06 .6
Tissue factor, ng/mL 3.1 ± 0.06 3.3 ± 0.2 3.0 ± 0.2 .5
VWF, ng/mL 444 ± 48 348 ± 152 344 ± 92 .98
  • Plasma was obtained from uninfected mice or on day 4 of P berghei infection after injection with either anti-CD41 mAb or rat IgG on day 1 of P berghei infection. Mean plus or minus the standard error (SE) is reported. P indicates statistical significance by ANOVA for anti-CD41 mAb-treated group and rat IgG-injected group.