Table 1.

Protocol scheme

Study phase and weekVitamin K intake, μg/day
Adjustment
1 0
2 0
3 0
4 0
Phase I: vitamin K from dietary supplements
5 50
6 100
7 150
8 200
9 250
10 300
11 500
Washout phase
12 0
13 0
Phase II: vitamin K from foods (single meals)
14 1500*
15 700*
16 103
17 1000
  • Vitamin K intakes shown are the supplement doses that each subject received above the intakes obtained from the regular diet (≈ 55 μg/day). In each week the INR was measured 4 times (on Mondays, Tuesdays, Wednesdays, and Fridays), whereas FIIc, FVIIc, ucFII, ucOC, cOC, vitamin K, and TAG were measured twice weekly (on Mondays and Tuesdays).

  • * K1.

  • MK-9.

  • MK-7.