Table 1.

SU11657 target profiles

Biochemical IC50, μMCell kinase assay cellular IC50, μMLigand-dependent synthesis cellular IC50, μM
PDGFβR 0.001 0.01-0.1 0.01
Flk-1/KDR 0.01 0.005-0.05
Flt3-ITD 0.05
c-Kit 0.01-0.05
EGFR > 20 23
  • IC50 values for SU11657 in selected biochemical and cellular assays are shown. Assays were performed as previously described.7 IC50 indicates concentration that inhibits 50%;—, not determined; and EGFR, epidermal growth factor receptor.