Table 1.

Demographics and MRI data from patients with SCA and TM.

ParameterSCATMPNormal reference range
Age, y 17.6 ± 1.3 15.7 ± 1.4 .23
Sex, M/F 9/8 10/9 .999
Hepatic iron concentration, mg/g dry weight 19.3 ± 3.7 18.4 ± 3.8 .997
Ferritin concentration 5422 ± 855 3648 ± 1378 .37
Transfusion duration, y 9.3 ± 1.3 12.2 ± 1.5 .20
Chelation duration, y 6.9 ± 1.2 9.8 ± 1.5 .23
BSA, m2 1.57 ± 0.09 1.25 ± 0.06 .002*
Pretransfusion hemoglobin level, g/L 94 ± 1 92 ± 1 .08
Heart rate, bpm 89.6 ± 3.6 84.1 ± 3.5 .18
Systolic blood pressure, mm Hg 116.9 ± 2.5 105 ± 2.3 .001*
Diastolic blood pressure, mm Hg 63.5 ± 1.9 60.2 ± 1.8 .02*
T2*, ms 38.1 ± 2.5 26.1 ± 4.6 .005* 25-46
LV ejection fraction, % 71 ± 2 67 ± 2 .14 61-7714
LV end-diastolic volume index, mL/m2 90.0 ± 5.4 85.9 ± 3.9 .53 36-8014
LV end-systolic volume index, mL/m2 26.1 ± 2.2 29.1 ± 2.8 .41 5-3114
LV mass index, g/m2 77.0 ± 4.8 63.4 ± 3.2 .008* 6-9514
Cardiac index, L/min/m2 5.9 ± 0.5 4.6 ± 0.2 .03* 1.7-4.013
  • Data represent the mean value ± SE. Right hand column demonstrates 95% confidence intervals for MRI values; however, all statistical comparisons are between the two patient populations. — indicates not assessed.

  • * Significant P value.