Table 3.

Acute events recorded during 5-year follow-up of 236 SS children accounting for 983 patient-years of observation

First year Total study period, 5 y
Events Patients, n Episodes, n Patients, n Episodes, n Incidence per 100 patient-years
Transfusions 24 31 46 56 5.7
Hospitalization 29 35 56 71 7.2
Pneumonia 51 57 72 101 10.3
Painful crises 123 255 183 610 62.2
Aplastic crisis 10 10 19 19 1.9
Acute splenic sequestration 7 10 7 10 1.0
Meningitis* 0 0 1 1 0.1
Malaria 12.8
    With fever 48 55 70 91
    Without fever 15 17 31 35
Stroke 1 1 4 4 0.4
Deaths 7 10 1.0
  • * Fatal Streptococcus pneumoniae meningitis. — indicates not applicable