Table 3.

Relationship between the factor XIIIA Val34Leu polymorphism and thrombotic disease

DiseaseAssociation with diseaseNo. subjects (controls)Origin of subjectsOdds ratioAuthor
MI+398 (196)Northern UK0.67 (0.54-0.85)Kohler et al108
MI+470Finland0.59 (0.38-0.93)Wartiovaara et al127
MI+150 (150)Brazil0.6 (0.4-0.9)Franco et al128
MI201 (244)Southern FranceNACanavy et al131
MI423 (479)USNAAleksic et al132
MI191UK AsiansNAWarner et al134
MI+120 (120)Northern Italy0.59Gemmati et al129
ICH+130 (130)Northern Italy1.74Gemmati et al129
BI+120Northern Italy0.60Gemmati et al129
MI3-150 +68US0.8Reiner et al130
BI3-150 41 (345)USNAReiner et al130
MI101Southern SpainNACorral et al133
DVT97Southern SpainNACorral et al133
CVD104Southern SpainNACorral et al133
DVT+226 (254)Northern UK0.63 (0.38-0.82)Catto et al136
DVT+189 (189)Brazil0.16 (0.05-0.5) for homozygous LeuFranco et al137
DVT+154 (308)Austria0.7 (0.5-1.0)Renner et al138
DVT273 (288)HungaryNABalogh et al114
DVT427 (1045)Southern ItalyNAMargaglione et al139
ICH+612 (436)Northern UKCatto et al143
BI+456 (456)France0.58 (0.44-0.75)Elbaz et al145
ICH201 (201)Southern SpainNACorral et al144
RAO+108 (313)Austria0.22 for homozygous LeuWeger et al147
  • MI indicates myocardial infarction; ICH, intracranial hemorrhage; BI, brain infarction; TIA, transient ischemic attack, DVT, deep vein thrombosis; CVD, cerebrovascular disease; RAO, retinal artery occlusion; and NA, not applicable.

  • F3-150 Subjects were all young women.