Table 3

Cytogenetic entities predicting significantly poorer overall survival in multivariable analysis

FactorHR99% CIP to enter model
Individual abnormalities
    Age, per year1.0181.013-1.023
    WBC, per unit increase1.0031.002-1.003
    Secondary disease1.541.31-1.82
    Performance status1.151.09-1.21
    −51.821.34-2.48< .001
    del(5q)/add(5q)1.731.37-2.19< .001
    inv(3)2.521.76-3.62< .001
    abn(3q)1.851.38-2.48< .001
    −71.511.22-1.88< .001
    t(10;11)2.621.59-4.29< .001
    +81.331.12-1.57< .001
    abn(17p)1.631.21-2.20< .001
    −171.581.15-2.17< .001
    t(6;11)2.251.26-4.03< .001
    add(7q)/del(7q)1.341.05-1.72.003
    t(11q23)*1.551.06-2.28.003
    t(9;22)1.641.04-2.56.004
Additional effect of complexity in above model
    > 3 abnormalities1.581.29-1.93< .001
  • CI indicates confidence interval; HR, hazard ratio; and WBC, white blood cell.

  • * Excluding t(9;11)(p21∼22;q23) and t(11;19)(q23;p13).