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Selection of Unrelated Donors and Cord Blood Units for Hematopoietic Cell Transplantation: Guidelines from NMDP/CIBMTR

Jason Dehn, Stephen Spellman, Carolyn K. Hurley, Bronwen E. Shaw, Juliet N. Barker, Linda J. Burns, Dennis L. Confer, Mary Eapen, Marcelo Anibal Fernandez-Vina, Robert Hartzman, Martin Maiers, Susana R. Marino, Carlheinz Mueller, Miguel-Angel Perales, Raja Rajalingam and Joseph Pidala

Abstract

Allogeneic hematopoietic cell transplantation involves consideration of both donor and recipient characteristics to guide the selection of a suitable graft. Sufficient high resolution donor-recipient human leukocyte antigen (HLA) match is of primary importance in transplantation with adult unrelated donors, using conventional graft-versus-host disease prophylaxis. In cord blood transplantation, optimal unit selection requires consideration of unit quality, cell dose and HLA-match. In this summary, the National Marrow Donor Program® (NMDP) and the Center for International Blood and Marrow Transplant Research® (CIBMTR), jointly with the NMDP Histocompatibility Advisory Group, provide evidence-based guidelines for optimal selection of unrelated donors and cord blood units.

  • Submitted April 19, 2019.
  • Revision received July 9, 2019.
  • Accepted June 24, 2019.