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An etiological role for the Epstein-Barr virus in the pathogenesis of classical Hodgkin lymphoma

Paul G. Murray and Lawrence S. Young

Abstract

While a pathogenic role for the Epstein-Barr virus (EBV) is largely undisputed for tumours that are consistently EBV genome positive (e.g. nasopharyngeal carcinoma, endemic Burkitt lymphoma), this is not the case for classical Hodgkin lymphoma (cHL), a tumour with only a variable EBV association. In light of recent developments in immunotherapeutics and small molecules targeting EBV, we believe it is now timely to re-evaluate the role of EBV in cHL pathogenesis

  • Submitted March 12, 2019.
  • Revision received June 11, 2019.
  • Accepted June 6, 2019.