Neutrophils as regulators of the hematopoietic niche

Itziar Cossío, Daniel Lucas and Andrés Hidalgo


The niche that supports hematopoietic stem and progenitor cells (HSPC) in the bone marrow is a highly dynamic structure. It maintains core properties of HSPC in the steady state, and modulates their proliferation and differentiation in response to changing physiological demands or pathological insults. The dynamic and environment-sensing properties of the niche are shared by the innate immune system. Thus, it is not surprising that innate immune cells, including macrophages and neutrophils, are now recognized as important regulators of the hematopoietic niche, and ultimately of the stem cells from which they derive. This review synthesizes emerging concepts on niche regulation by immune cells, with a particular emphasis on neutrophils. We argue that the unique developmental, circadian and migratory properties of neutrophils underlie their critical contributions as regulators of the hematopoietic niche.

  • Submitted October 29, 2018.
  • Accepted December 3, 2018.