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Dissecting CLL through high dimensional single cell technologies

Satyen Gohil and Catherine J. Wu

Abstract

We now have the potential to undertake detailed analysis of the inner workings of thousands of cancer cells, one cell at a time, through the emergence of a range of techniques probing the genome, transcriptome and proteome, combined with the development of bioinformatics pipelines that enable their interpretation. This provides an unprecedented opportunity to better understand the heterogeneity of the disease and how mutations, activation states and protein expression at a single-cell level impact disease course, response to treatment and outcomes. Herein, we review the emerging application of these new techniques to chronic lymphocytic leukemia and examine the fresh insights already attained through this transformative technology.

  • Submitted September 24, 2018.
  • Accepted November 7, 2018.