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How I treat primary mediastinal B-cell lymphoma

Lisa Giulino-Roth

Abstract

The WHO now recognizes primary mediastinal B-cell lymphoma (PMBCL) as a unique clinical and biologic entity. PMBCL is distinct from other B-cell non-Hodgkin lymphoma subtypes and has features that overlap with classical Hodgkin lymphoma including a peak incidence in the adolescent and young adult population; mediastinal presentation of disease, and molecular alterations in JAK2 and programmed death ligands. Since PMBCL is rare, there are few prospective clinical trials to guide therapy, resulting in no single standard of care. Given the long life expectancy of survivors of PMBCL, treatment approaches must balance maximizing cure while minimizing long term toxicity. In this article, I review my approach to the treatment of PMBCL, incorporating data from both adult and pediatric studies as well as recent advances in our understanding of the molecular basis of PMBCL.

  • Submitted April 5, 2018.
  • Accepted June 26, 2018.